Major structural protein of inner root sheath cells and medulla of hair follicle, present in small amounts in other specialised epithelia. Trichohyalin is a high molecular weight alpha-helix-rich protein that forms rigid structures as a result of postsynthetic modification by transglutaminases that cross-link the proteins and peptidyl-arginine deiminase that converts arginine to citrulline and modifies structure of the protein. Modified trichohyalin is thought to serve as a keratin intermediate filament-associated matrix protein, like filaggrin.
Dictionary of molecular biology. 2004.
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trichohyalin — A substance of the nature of keratohyalin found in the developing inner root sheath of the hair follicle. * * * tricho·hy·a·lin (trik″o hiґə lin) [tricho + hyalin] a protein found in granules in the cytoplasm of the cells of the Huxley … Medical dictionary
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Cornification — is the process of forming an epidermal barrier in stratified squamous epithelial tissue. At cellular level cornification is characterised by* production of keratin * production of small proline rich (SPRR) proteins and transglutaminase which… … Wikipedia
involucrin — Marker protein for keratinocyte differentiation first appearing in the upper spinous layer of the epidermis. Together with trichohyalin forms the scaffold for the cell envelope … Dictionary of molecular biology
peptidyl-arginine deiminase — EC 18.104.22.168 Enzyme responsible for formation of protein bound citrulline, a major amino acid in the inner root sheath and medulla of the hair follicle. Substrate is trichohyalin and postsynthetic modification of trichohylain by PAD alters its… … Dictionary of molecular biology
THH — telangiectasia hereditaria haemorrhagica; trichohyalin … Medical dictionary